Scientist

Job Description:

Project Scope:

• The development and optimization of novel cell-based assays ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets.
• Design, implement, and optimize gene-editing workflows in a manner that enables development and evaluation of cell-based functional assays supporting therapeutic target screening or lead optimization studies.
• Investigate, identify, develop, and optimize new methods/techniques to generate reliable and reproducible data promptly.
• Semi-independently plan and implement experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem resolution skills.
• Maintain proficiency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in group discussions.
• Adherence to good laboratory conduct, documentation practices, and safety guideline

Top 3 Must Have Skill Sets:

• Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays (e.g., TR-FRET, BRET, AlphaLISA, HCS, luminescence and fluorescence-based reporter and/or label-free assays) with experience in the utilization of lab automation across assay development and screening
• Track record of developing, implementing, and performing novel cell-based screening assays in microtiter plates to support early drug discovery research
• Ability to design and implement gene editing (CRISPR knock out/in) workflows enabling the development of targets specific and disease-relevant cell-based assays.

Day to Day Responsibilities:

• The development and optimization of novel cell-based assays ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets
• Design and implement laboratory experiments, generate & interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents
• Design, implement, and optimize gene-editing workflows in a manner that enables development and evaluation of cell-based functional assays supporting therapeutic target screening or lead optimization studies

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