What are the responsibilities and job description for the Senior Principal Scientist position at Flare Therapeutics Inc.?
Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare’s drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.
We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.
In this role you will…
- Provide scientific leadership in cheminformatics and applied machine learning capabilities in the Flare Discovery group.
- Build up Flare’s cheminformatics and machine learning capabilities which will be applied in library design, hit identification, prioritization and hit-to-lead progression and help advance our lead optimization projects towards the clinic. This will include implementing machine learning methods for physicochemical property predictions as well as ADME / PK / tox endpoints.
- Work with research informatics and data teams to deploy enterprise-level cheminformatics and machine learning solutions across the discovery and medicinal chemistry groups.
- Oversee and own research data integration across the Flare Discovery group.
- In partnership with the Data Science team, manage bioassay data integration into the Flare data management platform (supporting early hit finding through DC candidate identification) and help lab scientists analyze and report project data efficiently.
- Guide the design of compound-focused data analysis dashboards to enable multiparameter optimization and comprehensive decision-making in lead optimization.
- Act as the primary point of contact between the discovery research organization and scientific computing, computational biology, and data science teams.
About you…
Flare Therapeutics is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
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