Scientist/Senior Scientist - In Vivo Biology

Scientist/Senior Scientist - In Vivo Biology (Neuroscience)

Company Overview

GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer in synthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency and speed. GC Therapeutics is based in Cambridge, MA. For additional information, please visit www.gc-tx.com.

Job Purpose

GC Therapeutics is seeking a talented and highly motivated scientistfor our neuroscience program. The successful candidate will play a central role in advancing GC Therapeutics' neuroscience pipeline by leading the design and execution of in vitro and in vivo studies. The role demands hands-on experimental work with rodents, strategic project planning, regulatory support, and cross-functional collaboration to accelerate therapeutic development.

Duties and Responsibilities

• Design and implement in vitro and in vivo studies to support data-driven decision-making and rapid pipeline advancement.
• Perform rodent handling, dosing, necropsy, CNS tissue collection, processing, histological analysis, and imaging; manage genetic analysis and colony maintenance.
• Perform cell cultures and associated molecular biology and cell-based assays to characterize cell product.
• Generate, analyze, and interpret preclinical data; communicate findings clearly and promptly to supervisors and project teams.
• Oversee both GLP and non-GLP studies internally and through CROs; act as the primary liaison with external vendors to ensure scientific rigor and on-time deliverables.
• Participate in KOL interactions, contribute to indication prioritization and competitive landscape assessments.
• Contribute to drafting the nonclinical sections of regulatory submissions (e.g., INDs).
• Help establish and maintain IACUC protocols and ensure compliance with animal welfare regulations.
• Maintain detailed laboratory notebooks, summarize findings, and prepare presentations for internal meetings.
• Stay current with emerging literature in neuroscience, cell therapy, and assay technologies, and proactively recommend innovative approaches to drive research program advancement
• Collaborate effectively within the research team and across GC Therapeutics to achieve strategic goals.
• Consistently adhere to laboratory safety procedures and company policies.

Essential Qualifications:

• Ph.D. in neuroscience, cell biology, or a related field with a minimum of 5 years of postdoctoral laboratory experience in academic or industry settings
• Proficiency in stereotaxic surgery for mono- or multifocal CNS injections in rodents.
• Skilled in CNS tissue processing, immunohistochemistry, and confocal microscopy.
• Able to manage tasks independently while collaborating with junior staff and external partners.
• Demonstrated ability to strategically map data gaps and guide IND-enabling studies with scientific foresight.
• Proficient in the analysis, documentation, and communication of complex data sets; capable of preparing detailed scientific reports.
• Excellent multitasking and organizational skills to manage timelines and deliverables.
• Comfortable spending ~75% of time performing lab-based work, including occasional weekend hours.
• Proficient in in vitro cell culture techniques, general molecular biology techniques (e.g. DNA and RNA extraction, and PCR), assay development and troubleshooting. Experience with iPSC culture is a plus. Proficient in in vitro cell culture, molecular biology techniques (e.g., DNA/RNA extraction, PCR), and cell-based assays such as flow cytometry. Experience with iPSC culture is a plus.

Additional Preferred Qualifications:

• Proven track record and strong publications in neuroscience, animal work and preclinical studies within the industry.
• Expertise in cell therapy, and routes of administration for preclinical animal models of disease.