What are the responsibilities and job description for the Sr. Manager, Clinical Pharmacology position at Kriya Therapeutics, Inc.?
About Kriya
Kriya is a biopharmaceutical company whose mission is to develop life-changing gene therapies for diseases affecting millions of patients around the world.
We leverage our proprietary computational engine, in-house manufacturing infrastructure, and integrated design platform to engineer technologies and therapeutics with the potential to transform the treatment of a broad universe of diseases of high unmet need, with a focus on metabolic disorders, neurology, and ophthalmology.
We are proud to have been named Triangle Business Journal’s Life Sciences 2024 “Best Private Company to Work For,” recognized by Forbes as one of “America’s Best Startup Employers of 2024,”and honored as one of BioSpace’s “2025 Best Places to Work.”
Role Overview
The Senior Manager, Clinical Pharmacology, will play a vital role in advancing Kriya’s pipeline by implementing pioneering clinical pharmacology and Model-Informed Drug Development approaches. You will primarily be responsible for supporting quantitative decision-making in product life cycle by implementing population PK, PK/PD, exposure-response modelling and simulation to support drug development. This role requires the ability to work across a variety of therapeutic indications and data types. This position will represent the Clinical Pharmacology function on development teams and collaborate with other disciplines, including clinical development, biostatistics, regulatory, and more, to ensure consistent contributions across therapeutic areas.
Key Responsibilities
We have an ambitious set of goals, but our confidence – and our inspiration – stems from our people. From California to North Carolina, our teammates bring a spirit of Collaboration, Leadership, and Innovation to their work every day.
We’re always looking for teammates with the drive and energy to help us grow. If you want to be a part of a company with an entrepreneurial culture, a bold vision, and a meaningful purpose, join us.
Rewards & Benefits
Medical, Dental and Vision ∙ 401(k) with Company Match ∙ Short and Long-term Disability Benefits ∙ Company Paid Holidays ∙ Flexible Time Off ∙ Cyber Safety protection ∙ EAP ∙ Life Insurance ∙ Equity ∙ and more!
Kriya is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
All job requirements in the job description provided indicate the minimum level of knowledge, skills, and/or abilities deemed necessary to perform the job competently. Job descriptions are an overview of the duties, responsibilities, and requirements of the position. Employees may be required to perform other job-related assignments as requested.
Kriya is a biopharmaceutical company whose mission is to develop life-changing gene therapies for diseases affecting millions of patients around the world.
We leverage our proprietary computational engine, in-house manufacturing infrastructure, and integrated design platform to engineer technologies and therapeutics with the potential to transform the treatment of a broad universe of diseases of high unmet need, with a focus on metabolic disorders, neurology, and ophthalmology.
We are proud to have been named Triangle Business Journal’s Life Sciences 2024 “Best Private Company to Work For,” recognized by Forbes as one of “America’s Best Startup Employers of 2024,”and honored as one of BioSpace’s “2025 Best Places to Work.”
Role Overview
The Senior Manager, Clinical Pharmacology, will play a vital role in advancing Kriya’s pipeline by implementing pioneering clinical pharmacology and Model-Informed Drug Development approaches. You will primarily be responsible for supporting quantitative decision-making in product life cycle by implementing population PK, PK/PD, exposure-response modelling and simulation to support drug development. This role requires the ability to work across a variety of therapeutic indications and data types. This position will represent the Clinical Pharmacology function on development teams and collaborate with other disciplines, including clinical development, biostatistics, regulatory, and more, to ensure consistent contributions across therapeutic areas.
Key Responsibilities
- Offer scientific and strategic input into Therapeutic Area clinical pharmacology plans.
- Identify, develop, and carry out strategic clinical pharmacology activities.
- Assist in the development and validation of pharmacometrics models.
- Oversee CRO collaboration on clinical pharmacology projects
- Conduct population pharmacokinetic and pharmacodynamic analyses.
- Provide pharmacometrics expertise to project teams.
- Collaborate with cross-functional teams to support the design and execution of clinical studies (early and late phase trials).
- Lead the development of the clinical pharmacology sections of clinical protocols and associated analysis plans
- Prepare relevant sections and review regulatory submissions.
- Collaborate with academic institutions and key opinion leaders
- Stay current with scientific literature and regulatory guidance
- PhD degree (in pharmacometrics, pharmaceutical sciences, or related field) preferred or equivalent relevant experience.
- 4 years of progressive experience.
- Minimum of 4 years of experience in PK/PD modelling, preferably in biologics.
- An equivalent combination of education and experience is acceptable
- Strong knowledge of pharmacokinetics and pharmacodynamics.
- Experience with population PK/PD modeling and simulation.
- Experience with NONMEM, R, or other pharmacometrics software.
- Excellent communication and interpersonal skills.
- Ability to work independently and collaboratively in a fast-paced environment.
- Prior experience of regulatory filings and knowledge of regulatory compliance processes specific to clinical pharmacology is preferred.
- Primarily desk-based, generally in an office or home office setting
- May involve extended periods of sitting and computer use.
We have an ambitious set of goals, but our confidence – and our inspiration – stems from our people. From California to North Carolina, our teammates bring a spirit of Collaboration, Leadership, and Innovation to their work every day.
We’re always looking for teammates with the drive and energy to help us grow. If you want to be a part of a company with an entrepreneurial culture, a bold vision, and a meaningful purpose, join us.
Rewards & Benefits
Medical, Dental and Vision ∙ 401(k) with Company Match ∙ Short and Long-term Disability Benefits ∙ Company Paid Holidays ∙ Flexible Time Off ∙ Cyber Safety protection ∙ EAP ∙ Life Insurance ∙ Equity ∙ and more!
Kriya is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
All job requirements in the job description provided indicate the minimum level of knowledge, skills, and/or abilities deemed necessary to perform the job competently. Job descriptions are an overview of the duties, responsibilities, and requirements of the position. Employees may be required to perform other job-related assignments as requested.