Post-Doctoral Fellow (RNA Biology and Therapeutics) - Lab-Tian

The Wistar Institute has an opening for a motivated candidate to join the Bin Tian lab as a Post-Doctoral Fellow to study the regulation of pre-mRNA processing in cancer and inflammation using molecular and cellular biology techniques and to develop related anti-cancer and anti-inflammation therapeutics. One area of research is to examine the impact of dysregulated cleavage and polyadenylation (CPA) in oncogenesis and cancer cell drug resistance.  A second area of research is to develop effective CPA-based therapeutics, involving small molecules, antisense oligos or mRNA-based technologies.    Candidates should have a Ph.D. or equivalent degree in molecular biology, cancer biology, or a related field. The successful candidate is expected to have good communication skills that are necessary for effective collaborations. Interested candidates should apply online as well as providing a CV including a summary of previous research and contact information of three referees to Dr. Bin Tian (btian@wistar.org).   The Tian lab uses interdisciplinary approaches to study mRNA biogenesis and metabolism, with a special focus on the molecular mechanisms and cellular consequences of alternative cleavage and polyadenylation (APA). We employ a variety of cutting-edge techniques spanning multiple fields, including molecular and cellular biology, genomics, bioinformatics, and advanced imaging. Detailed research topics and publications can be found at https://wistar.org/our-scientists/bin-tian.   The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health.    The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides outstanding intellectual environments and state-of-the-art facilities.