What are the responsibilities and job description for the Analytical Chemist position at Hydrogen Group?
Analytical Chemist
Boston, MA
Schedule: Hybrid - 3 days onsite
Duration: 12-Month Contract (opportunity to extend)
Pay: $66-71/hr (W2)
Our client is a leading biotechnology company specializing in advanced therapeutics. They are seeking an experienced Analytical Chemist to join their growing Technical Operations Analytical team. This hybrid role has the primary responsibility to provide analytical support for Oligonucleotides and Peptides in late-stage phase, with opportunities to lead method development and validation activities independently.
Essential Functions and Responsibilities
- Provide analytical support for Oligonucleotide and Peptide-Oligonucleotide conjugated compounds
- Develop and optimize robust LC/MS, IPRP, and SAX HPLC analytical methods for analysis and purification of highly modified oligonucleotide drug substances
- Utilize IP-RP-HPLC, AX-HPLC, UPLC, LC-MS, and LC-MS/MS analytical techniques using Agilent, Waters, and/or Thermo instruments and associated software
- Operate, maintain, and troubleshoot laboratory instruments
- Perform method validation and transfer activities in compliance with GLP/GMP standards
- Collect, document, and analyze test data with strict attention to detail
- Draft technical reports, analytical methods, and validation documentation
- Collaborate with cross-functional teams across Technical Operations
- Train and mentor team members on analytical procedures and instrumentation
- Support late-stage phase analytical activities for oligonucleotide therapeutics
Education and Experience
- MS or BS in Chemistry, Analytical Chemistry, or related field
- 3 years of industrial experience in pharmaceutical or biotechnology environment
- Strong background in analytical development and validation of methods for analysis of oligonucleotide therapeutics required
- Experience with late-stage phase analytical support preferred
Knowledge and Skills
- Strong background in analytical development and validation of oligonucleotide therapeutics
- Strong knowledge of mass spectrometry and purification techniques
- Expertise with IP-RP-HPLC, AX-HPLC, SAX-HPLC, UPLC, LC-MS, and LC-MS/MS analytical techniques
- Experience with Agilent, Waters, and/or Thermo instrumentation and associated software
- In-depth knowledge of GLP/GMP requirements in a pharmaceutical environment
- Knowledge of cGMP practices and documentation requirements
- Strong problem-solving methodology and root cause analysis skills
- Excellent technical writing and communication skills
- Demonstrated ability to work independently and with cross-functional teams
- Committed team player and collaborator
- Ability to operate, maintain, and troubleshoot complex laboratory instruments
- Strong attention to detail and organizational skills
- Computer skills including MS Office Suite and chromatography data systems
- Ability to develop and optimize robust analytical methods
- Knowledge of validation and method transfer processes
Salary : $66 - $71