Postdoctoral fellow

Job title: Postdoctoral position (Lee Lab, Unit on Functional Neural Circuits)

Employer: National Institute of Mental Health (NIMH), National Institutes of Health (NIH)

Location: Bethesda, Maryland, USA

Description: A postdoctoral position is available in Lee lab (Unit on Functional Neural Circuits).

My lab studies the organization of neural circuits that enable corticocortical communication and support the computations of dynamic interactions between sensory and behavioral functions using rodents and non-human primate (marmoset). To comprehend how the neocortex integrates and contextually computes relevant incoming information, a mechanistic understanding of the recruitment and role of the various cellular and circuit elements within the corticocortical communication is imperative. We aim 1) to unravel the circuit mechanisms, at a neuronal resolution, through which diverse internal states are transmitted and integrated in relevant brain areas, 2) to determine the behavioral significance of these circuits, 3) to understand the computations they perform, and 4) to explore how such circuit mechanisms emerge during development and adapt through experiences. We focus on motor-sensory processing in somatosensory cortex and connected brain areas of the mouse. We use a combination of methods, including diverse imaging, in vitro and in vivo electrophysiological recordings, optogenetics, chemogenetic, genetic labelling and anatomical tracing, genetic analysis and computational analysis.

We are looking for highly talented and motivated postdoctoral fellows who have a MD/PhD or PhD in Neuroscience or related disciplines and who have a record of research productivity. We are particularly interested in candidates who have strong quantitative and programming skills and experience in at least one of the following tools: imaging, electrophysiology (in vitroand/orin vivo), and behavioral study. Scientific creativity and communication skills are also important as the candidates will work both independently and as part of a team. Salary will be commensurate with education and experience.

Start date: flexible

Stipend:

Contact:

Publications

From Lee Lab

1. Inacio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S. bioRxiv 2023.05.25.542329. PMID: 37425800 (under revision) Rhodes CT, Asokumar D, Sohn M, Naskar S, Elisha L, Stevenson P, Lee DR, Zhang Y, Rocha PP, Dale RK, Lee S, Petros TJ. bioRxiv 2023.09.06.556544 (under review) Naskar S, Inacio AR, Stevenson P, Qi J, Lee S. Development of cortical disinhibitory circuit (under review) Naskar S, Stevenson P, Ye C, Qi J, Lee S. Reduction of SynGAP1 in cortical Parvalbumin-positive GABAergic neurons impairs long-range cortico-cortical connectivity. (under review) Qi J, Ye C,Naskar S, Inacio AR, Lee S. . PLoS Biol. 2022 Nov 28;20(11):e3001896. PMID:36441759 Jung WB, Jiang H, Lee S, Kim SG. . Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2113313119. PMID: 35042795 Zagha E, Erlich JC,Lee S, Lur G, O'Connor DH, Steinmetz NA, Stringer C, Yang HJ. . Journal of Neuroscience. 2022 Jan 6:JN-TS-1919-21. PMID:35027407 Naskar S, Qi J, Pereira F, Gerfen CR and Lee S. Cell Reports. 2021 Feb 23;34(8):108774. doi: 10.1016/j.celrep.2021.108774, PMID: 33626343

From previous works

1. He M, Tucciarone J,Lee S, Nigro MJ, Kim Y, Levine JM, Kelly SM, Krugikov I, Wu P, Chen Y, Gong L, Hou Y, Osten P,Rudy B, Huang ZJ. . Neuron 91(6):1228-43, 2016. PMID: 27618674 Tremblay R,Lee S,Rudy B. . Neuron 91(2):260-92,2016. PMID: 27477017 Lee S, Kruglikov I, Huang J, Fishell G, Rudy B. Nature Neuroscience 16(11):1662-70, 2013. PMID: 24097044 Rudy B, FIshell G, Lee S, Hjerling-Leffler J. . Dev. Neurobiol. 71(1):45-61, 2011. PMID: 21154909 Lee S, Hjerling-Leffler J, Zagha E, Fishell G, Rudy B. . Journal of Neuroscience 30(50):16796-808, 2010. PMID: 21159951 Lee S, Carvell G, Simons DJ. Nature Neuroscience 11(12):1430-8, 2008. PMID: 19011625