Nighttime Operations Lead

Nighttime Operations Lead – Key Leadership Role for Overnight Operations

Location: Onsite (Frederick, MD)

Salary Range: $58,000 – $62,000 (based on experience and tenure)

Status: Full-Time, Exempt, Night Shift

Schedule: Wednesday to Sunday, 9:00 PM – 6:30 AM

Reports To: Operations Manager

About SBS: SriSai Biopharmaceutical Solutions (SBS) is a mission-driven biopharmaceutical company committed to operational excellence and life-changing scientific solutions. Our dedicated operations teams ensure 24/7 facility readiness, safety, and compliance to support our growing biotech operations.

Why This Role Matters: As Nighttime Operations Lead, you act as the senior operations authority onsite during overnight hours, ensuring continuous facility operations, safety, and compliance. This role requires a high level of independent judgment and is responsible for overseeing the smooth execution of multiple operational processes, supporting deviation responses, and making decisions aligned with SBS’s RICE values: Respect, Integrity, Customer-Centered, and Excellence.

Key Responsibilities:

• Serve as the top overnight operations leader onsite, authorized to make real-time decisions on operational priorities, safety responses, and escalation protocols.
• Monitor and ensure optimal performance of critical infrastructure such as HVAC, freezers (-20°C/-80°C), LN2 storage systems, and alarm systems.
• Provide Emergency Response Technician (ERT) coverage, managing incidents and making on-the-spot decisions to resolve or escalate emergencies.
• Exercise discretion in prioritizing overnight tasks, managing unexpected operational challenges, and making facility decisions independently.
• Perform routine cleaning, sanitization, and minor maintenance tasks as needed to maintain operational readiness.
• Conduct environmental monitoring (temperature, humidity, particle counts), interpret data, and initiate responses to out-of-spec conditions.
• Keep accurate and professional documentation in electronic logs, batch records, and deviation reports.
• Lead overnight incident documentation and collaborate on root cause analysis.
• Facilitate smooth shift handoffs, preparing summary reports for day shift leadership.
• Communicate independently with Inventory, Facilities, Validation, and Quality teams on operational needs during unsupervised hours.
• 
  

Key Qualifications:

• Strong understanding of GMP environments, facility systems, and safety compliance protocols.
• Proven ability to work independently, manage complex operational workflows, and make time-sensitive decisions.
• 5 years of operational facility experience, with demonstrated ability to troubleshoot and resolve onsite operational issues.
• Proficiency in operational documentation, SOP adherence, and reporting.

Preferred Experience:

• Prior cross-functional experience in facility, validation, or quality operations.
• Familiarity with biotech manufacturing and regulated environments.
• Commitment to acting as an overnight operational leader with sound judgment and escalation authority.

Why SBS? At SBS, we invest in people dedicated to operational excellence and independent leadership. This role offers autonomy, professional responsibility, and recognition of your operational expertise. Our RICE values guide our culture:

• Respect: We treat everyone with dignity and professionalism.
• Integrity: We do the right thing, always.
• Customer-Centered: We support both internal and external customers.
• Excellence: We uphold the highest standards in everything we do.

Equal Opportunity Employer: SriSai Biopharmaceutical Solutions is proud to be an Equal Opportunity Employer. We foster a workplace built on respect, equity, and inclusion.

Ready to lead overnight operations with autonomy and impact? Apply today to be part of SBS’s core operational leadership team.’s core operational leadership team.

Salary : $58,000 - $62,000